Griseofulvin in Leprosy

Limited pilot trial. Treatment of leprosy by griseofulvin.

Because of the interest in Griseofulvin in respect to its fungicidal properties, it was felt that it would be useful to undertake a very l i mited prel iminary trial in order to ascerta in whether Griseofulvin has any effect on the M. leprae. Early workers, particularly REEN­ STIERNA, was of the opinion that M. leprae was originally a so i l fungus and, over the centuries, adapted itself to hu ...

Ketoconazole in griseofulvin-resistant dermatophytosis.

The efficacy of ketoconazole was evaluated in twenty patients with chronic dermatophyte infections who had failed to clear with griseofulvin therapy. Trichophyton rubrum was the causative organism in nineteen of the patients, and Trichophyton mentagrophytes in one patient. Three of twelve organisms tested showed in vitro resistance to griseofulvin. Duration of infection ranged from 2 to 28 year...

Cardiovascular effects of griseofulvin.

The intravenous administration of griseofulvin in doses of 3.0 mg/kg to 32 anesthetized open-chest dogs produced marked increments (43%) in isometric systolic force measured by a strain gauge. These changes were accompanied by an increase (22%) in heart rate and a decrease (25%) in blood pressure. The effect was unaltered by clamping the blood supply to and from the adrenal glands or by previou...

The chemistry of griseofulvin.

Effects of griseofulvin in experimental rabbit syphilis.

We have previously reported the effects of some antibiotics on experimental rabbit syphilis (Fujita, Asada, and Amawashi, 1962). The recent resurgence of infectious syphilis has led us to look for more effective anti-luetic agents. From this point of view we are studying the ultrastructure of spirochaetes (Hasegawa, Sasahira, and Matsuura, 1965; Hasegawa and Sasahira, 1965; Hasegawa, Komura, an...